Santa Cruz Vacations

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Your Santa Cruz Vacation

With one of our vacation packages to Santa Cruz, you'll find countless opportunities for adventure and relaxation. There's so much to experience, including its beaches and lively atmosphere. If taking in sights is part of the program during your trip to Santa Cruz, check out major attractions like Plaza 24 de Septiembre, Guembe Biocenter and Ventura Mall. Whoever you're heading away with and whatever the size of your budget, your dream Santa Cruz vacation is just clicks away with Expedia.

Discover the most popular places to visit in Santa Cruz

Santa Cruz Hotel Deals

Ibis Santa Cruz DE LA Sierra

Ibis Santa Cruz DE LA Sierra

3 out of 5
AVENIDA CRISTOBAL DE MENDOZA, Santa Cruz
$43 nightly
The price is $43 total per night from Aug 27 to Aug 28
$43 total
Aug 27 - Aug 28
9.4/10 Exceptional! (49 reviews)
"The"

Reviewed on Jul 28, 2025

Ibis Santa Cruz DE LA Sierra
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

3.5 out of 5
Ave. San Martin, #455, Santa Cruz
$125 nightly
The price is $125 total per night from Aug 19 to Aug 20
$125 total
Aug 19 - Aug 20
8.8/10 Excellent! (322 reviews)
"Always an amazing hotel"

Reviewed on Jun 21, 2025

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Marriott Santa Cruz de la Sierra Hotel

Marriott Santa Cruz de la Sierra Hotel

5 out of 5
4to Anillo Entre Radial 23, At Calle Las Ramblas, Santa Cruz, Santa Cruz
$119 nightly
The price is $119 total per night from Aug 22 to Aug 23
$119 total
Aug 22 - Aug 23
9/10 Wonderful! (191 reviews)
"all"

Reviewed on Jun 5, 2025

Marriott Santa Cruz de la Sierra Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Things to do in and around Santa Cruz

Santa Cruz, Bolivia, offers a vibrant mix of city-themed and outdoor activities perfect for families and adventure seekers alike. Enjoy thrilling outdoor adventures like hiking and standup paddleboarding, or take a leisurely stroll through shopping centers and malls. For a fun-filled day, visit a local resort or try out roller coasters for an exhilarating experience. With something for everyone, Santa Cruz promises an unforgettable vacation.

Shopping

In Santa Cruz, explore Ventura Mall and Las Brisas Shopping Center for a vibrant shopping experience with entertainment and family-friendly options. If you're up for a drive, check out Warnes Plaza, located 19 miles away, offering similar attractions and a lively atmosphere.

Recreation

At Ramon Tahuichi Aguilera Stadium, immerse yourself in the vibrant sports atmosphere while enjoying local events. Experience family-friendly entertainment at Cine Center, perfect for a cozy movie night. For a taste of culture, visit Casa Municipal de Cultura Raúl Otero Reiche, where you can enjoy captivating performances and artistic displays.

Adventure

Explore the lush Amboró National Park, a paradise for hikers and wildlife enthusiasts, where you can trek through diverse ecosystems and spot unique flora and fauna. For adrenaline seekers, the nearby Lomas de Arena offers thrilling sandboarding experiences on massive dunes amidst stunning landscapes.

Nightlife

In Santa Cruz, enjoy vibrant nightlife at lively spots like Avenida Monseñor Rivero and Calle Libertad, where bars and clubs pulse with energy. Experience live music, dance the night away, and savor delicious Bolivian cocktails in a welcoming atmosphere that captures the spirit of the city.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Find the best attractions in Santa Cruz

Santa Cruz, Bolivia, is a vibrant city perfect for family-friendly and outdoor vacations. Visitors can explore popular attractions like the piazza square, impressive cathedral, and various landmarks. The city offers a rich cultural experience and a range of activities suitable for all ages. Whether you’re seeking a taste of local culture or outdoor adventures, Santa Cruz is an ideal destination for a memorable getaway.

  • Plaza 24 de Septiembre: This vibrant square is the heart of Santa Cruz, bustling with local culture and city vibes. Surrounded by charming colonial architecture, it’s perfect for people-watching or enjoying street performances, making it a lively hub for both locals and tourists.
  • Blacutt Square: A notable landmark in Santa Cruz, Blacutt Square offers a unique excursion vibe, often serving as a starting point for exploring the city's rich history and vibrant neighborhoods. It's an ideal spot for visitors seeking a blend of culture and adventure.
  • Lomas de Arena Regional Park: This stunning natural reserve features vast sand dunes and striking landscapes, providing a sunny weather vibe perfect for hiking, picnicking, and photography. It's a tranquil escape from the urban hustle, showcasing Bolivia's unique ecology.

Best time to go to Santa Cruz

The best time to visit Santa Cruz is dependant on what kind of holiday you are seeking. October is its hottest month on average. At this time, visitor numbers are slightly low and weather is mostly sunny with light rain. June is its coolest month on average. At this time, visitor numbers are average and weather is mostly sunny with light rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January78.3°F (25.7°C)Light RainMostly SunnySlightly HighAverage
February77.0°F (25.0°C)Light RainMostlyAverageAverage
March76.5°F (24.7°C)Light RainMostly SunnyAverageSlightly High
April74.5°F (23.6°C)Light RainMostly SunnyAverageSlightly High
May70.2°F (21.2°C)Light RainMostly SunnySlightly LowAverage
June67.8°F (19.9°C)Light RainMostly SunnyAverageSlightly Low
July68.5°F (20.3°C)No RainMostly SunnySlightly HighAverage
August72.9°F (22.7°C)No RainSunnyAverageSlightly Low
September77.9°F (25.5°C)Light RainSunnySlightly HighSlightly High
October79.5°F (26.4°C)Light RainMostly SunnySlightly LowAverage
November79.3°F (26.3°C)Light RainMostly SunnyAverageSlightly Low
December78.4°F (25.8°C)Light RainMostly SunnySlightly LowAverage

Tips to save on your trip to Santa Cruz

  • Take advantage of package deals on Expedia and combine flights, hotels, or car rentals for a convenient and cost-effective trip to Santa Cruz.
  • Consider traveling during the off-peak season (typically June, August and November) for more affordable package holidays to Santa Cruz.
  • Use the Price per traveler filter on Expedia to find a package deal that suits your budget.
  • Check the VIP Access properties filter to discover outstanding hotels with added member perks at select properties.

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Frequently asked questions

How much does a Santa Cruz vacation package cost?
You'll find cheap prices on Expedia for your Santa Cruz break. However, a range of factors like the hotel choice, length of stay and season will determine how much your vacation to Santa Cruz costs.
What are the cheapest months to go to Santa Cruz?
If you'd like to score a cheap Santa Cruz vacation package, consider traveling in January, May and December. You'll typically find lower rates on hotels and airfares during these quieter months — ideal for a budget-friendly getaway.
How many days is enough for Santa Cruz?
Generally, a handful of days is enough to tick off the main sights during your Santa Cruz vacation. However, if you prefer to have more time to rest or take day trips, think about extending your trip.
Is it worth booking a vacation package to Santa Cruz?
Santa Cruz is a good vacation destination with attractions like Plaza 24 de Septiembre among the many things to keep you entertained. Whether you're heading away with the family or getting away with friends, a Santa Cruz vacation promises a good time for everyone.
How to find the best Santa Cruz package deals?
Use Expedia's filters to help you find some tempting Santa Cruz package deals. When you start your search, simply set your maximum budget and then sort the results by "Price: low to high." If you're looking to save, plan your break for midweek, or look for Santa Cruz package deals in the off-peak season. Play around with your travel dates and you may land even better discounts. As a rule of thumb, it's usually best to lock in your vacation package as early as possible.
Is it cheaper to book a Santa Cruz vacation as a package?
You can enjoy significant savings on your Santa Cruz escape by booking a personalized vacation package. Click on the "Package" heading, then enter your travel dates and destination to browse some great hotel prices and airfares. Bundle everything into a great-value package and you can save hundreds of dollars. Consider adding a rental car and you may score a better deal.
When to book a vacation package to Santa Cruz?
If you're considering an impromptu Santa Cruz adventure, browse our last-minute deals that can be booked up to a week before you take off. Don't want to leave things to the last minute? You can find sensational deals on your flights and hotels by booking well in advance.
How to plan a trip to Santa Cruz?

  1. Choose your travel dates: What you plan to do in Santa Cruz and your preferred season can help you decide when to go.
  2. Calculate your budget: Ensure you have enough money to pay for everything from transportation and dining out to airfares and activities. Your hotel will likely be the largest expense during your trip to Santa Cruz.
  3. Discover Santa Cruz using Expedia's trip planning tool: Gain insights into the leading attractions and best stays for your trip to Santa Cruz. You can also save your favorite places, collaborate with family and friends and manage all your plans in one place.
  4. Decide how long to go for: Now that you're more familiar with Santa Cruz, you can work out the ideal length of your break. Create a rough plan and allocate enough time to cover everything you want to see.
  5. Bundle your accommodations and airfare: Once you've nailed down your dates and duration, lock in the ideal Santa Cruz vacation package for you.
  6. Book experiences or activities in advance: Whether it's a ticket to a major attraction or a day trip, you won't have to worry about missing out on the highlights of Santa Cruz. Find all the incredible things to do in Santa Cruz with our dedicated travel guide.

Does Expedia offer Book Now, Pay Later Santa Cruz vacation packages?
Your Santa Cruz break is meant to be an escape from your daily routine, not a source of money worries. So to give you a little more flexibility, we've teamed up with online lender Affirm to bring you our Book Now, Pay Later vacations. Pick one of our vacation packages with payment plans and break down the cost over 3, 6 or 12 months. Plus, there aren't any hidden costs or late payment fees to worry about.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.